11
Table 4. Examples of Adjuvant/Radiosensitizing Chemotherapy
Regimens in Anaplastic Thyroid Carcinoma
Regimen Agents/dosages Frequency
Paclitaxel //
carboplatin
Paclitaxel 50 mg/m
2
//
carboplatin AUC
a
2 mg/m
2
IV
Weekly
Docetaxel //
doxorubicin
Docetaxel 60 mg/m
2
IV //
doxorubicin 60 mg/m
2
IV (w/pegfilgrastim)
or
Every 3–4
weeks
Docetaxel 20 mg/m
2
IV //
doxorubicin 20 mg/m
2
Weekly
Paclitaxel Paclitaxel 30–60 mg/m
2
IV Weekly
Cisplatin Cisplatin 25 mg/m
2
IV Weekly
Doxorubicin Doxorubicin 60 mg/m
2
IV
or
Every 3 weeks
Doxorubicin 20 mg/m
2
IV Weekly
a
Carboplatin AUC, carboplatin dosed using the Calvert formula with the Cockro & Gault
equation, actual body weight, and using a minimum serum creatinine value of 0.7 mg/dL.
Table 5. Examples of Chemotherapy Regimens in Advanced
Anaplastic Thyroid Carcinoma
Regimen Agents/dosages Frequency
Paclitaxel //
carboplatin
Paclitaxel 60–100 mg/m
2
//
carboplatin AUC 2 mg/m
2
IV
Weekly
Paclitaxel 135–175 mg/m
2
//
carboplatin AUC 5–6 mg/m
2
IV
Every 3–4
weeks
Docetaxel //
doxorubicin
Docetaxel 60 mg/m
2
IV //
doxorubicin 60 mg/m
2
IV (w/ pegfilgrastim)
or
Every 3–4
weeks
Docetaxel 20 mg/m
2
IV //
doxorubicin 20 mg/m
2
IV
Weekly
Paclitaxel Paclitaxel 60–90 mg/m
2
IV Weekly
Paclitaxel 135–200 mg/m
2
IV Every 3–4
weeks
Doxorubicin
Doxorubicin 60–75 mg/m
2
IV
or
Every 3 weeks
Doxorubicin 20 mg/m
2
IV Weekly
