Comments Pediatric Dose Class (Adult/Child) 15 mg/kg/dose IV q6h A-II
6-10 mg/kg/dose IV daily
A-I/C-III
The addition of gentamicin‡ rifampin (A-I) to vancomycin‡§ routinely recommended.
(A-II) or is not
For adult patients, some experts recommend higher doses of 8-10 mg/kg/dose IV daily (B-III).
Pregnancy category B.
Evaluation for valve replacement surgery is recommended if large vegetation (> 10 mm in diameter), occurrence of ≥ 1 embolic events during the first two weeks of therapy, severe valvular insufficiency, valvular perforation or dehiscence, decompensated heart failure, perivalvular or myocardial abscess, new heart block, or persistent fevers or bacteremia (A-II).
15 mg/kg/dose IV q6h 1 mg/kg/dose IV q8h B-III
5 mg/kg/dose PO/IV q8h §
Early evaluation for valve replacement surgery is recommended (A-II).
Max: 2 gm/dose. In seriously ill patients consider a loading dose of 25-30 mg/kg (C-III).
|| Repeat blood cultures 2-4 days aſter initial positive cultures and as needed thereaſter are recommended to document clearance of bacteremia (A-II).
7
