Selecting a Treatment Regimen Figure 2. Cryptococcal
HIV-Infected Individuals
Induction Therapy
AmBd (0.7-1.0 mg/kg per day) plus flucytosine
(100 mg/kg per day)a Duration: 2 weeks (A-I)
OR Lipsomosal AmB (3-4 mg/kg per day) or ABLC (5
mg/kg per day, with renal function concerns) plus flucytosine (100 mg/kg per day)a
Duration: 2 weeks (B-II) OR
AmBd (0.7-1.0 mg/kg per day) or liposomal AmB (3-4 mg/kg per day) or ABLC (5 mg/kg per day,
for flucytosine-intolerant patients) Duration: 4-6 weeks (B-II)
Consolidation Fluconazole (400 mg per day) Duration: 8 weeks (A-I)
Alternatives to Induction Therapy
AmBd plus Fluconazole (B-I)
OR
Fluconazole plus flucytosine (B-II)
OR
Fluconazole (B-II)
OR
Itraconazole (C-II)
Maintenance
Fluconzole (200 mg per day)a Duration: ≥ 1 yearc
(A-I)
Alternatives for Maintenance Therapyb
Itraconazole (400 mg per day)d
Duration: ≥ 1 yearc (C-I) OR
AmBd (1 mg/kg per week)d Duration: ≥ 1 yearc (C-I)
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