> 
Suspected Appendicitis* Men: Initial Evaluation Typical 
presentation (≤ 24 h from 
symptom onset) Atypical presentation Women: Initial Evaluation 
Women not of childbearing age 
Women of child- bearing age 
Pregnancy test Negative > 3 months Either Helical CT Appendicitis Confirmed Unperforated Perforated Circumscribed 
peri-appendiceal abscess 
Peri-appendiceal phlegmon 
Antimicrobial therapy, antipyretics, and pain management Surgery 
≤ 24 h open or laparoscopic 
Urgent surgery- open or 
laparoscopic 
Optional non-operative management if improving† 
Uncertain Diagnosis Further evaluation 
scanning, or 24- hour observation 
Laparoscopy, limited CT 
therapy ≥ 3 days, antipyretics, and pain management 
Antimicrobial suspicion is high 
*Algorithm is not a part of the guidelines but is based on the ideas contained therein. †The use of interval appendectomy aſter percutaneous drainage or nonoperative management of perforated appendicitis may not be necessary. 
Continued observation in-hospital if 
Percutaneous or operative drainage† 
Careful inpatient follow-up 
Positive 
≤ 3 months US or MRI