Figure 1. Managing Treatment-Naïve Patients with Chronic HCV Infection, Genotype 1
Eligible Patient Anti-HCV Positive
Determine quantitative HCV RNA Determine HCV genotype
If genotype 1 Liver biopsy suggested More than portal fibrosis
Treat with PegIFN plus RBV; add boceprevir aſter 4 weeks
No cirrhosis OR Cirrhosis
Continue Rx for 48 weeks
Determine quantitative HCV RNA
at weeks 8, 12 & 24
Determine quantitative HCV RNA
at weeks 4, 12 & 24
Treat with PegIFN plus RBV; add telaprevir for the 1st 12 weeks
No cirrhosis No fibrosis or portal fibrosis only Consider no treatment
If HCV RNA undetectable at weeks 8 & 24,
consider 28 weeks total Rx
If HCV RNA > 100 IU/mL at week 12 or detectable at week 24, D/C Rx
If HCV RNA undetectable at weeks 4 & 12,
consider 24 weeks total Rx
If HCV RNA > 1000 IU/mL at weeks 4 or 12 and/or
detectable at week 24, D/C Rx 7
