14
Treatment
Table 1. Antimicrobial therapy for Staphylococcal and
Streptococcal SSTIs
a
Disease Entity Antibiotic Adult Dosage
Impetigo
c
(Staphylococcus and
Streptococcus)
Dicloxacillin (generic) 250 mg qid PO
Cephalexin
Keflex
®
, (generic)
250 mg qid PO
Erythromycin (generic) 250 mg qid PO
d
Clindamycin
Cleocin
®
, (generic)
300-400 mg qid PO
Amoxicillin/clavulanate
Augmentin
®
, (generic)
875/125 mg bid PO
Retapamulin ointment Altabax
®
Apply to lesions bid
Mupirocin ointment Bactroban
®
Apply to lesions tid
MSSA Nafcillin or oxacillin (generic) 1-2 g q4h IV
Cefazolin
®
(generic)
1g q8h IV
Clindamycin
Cleocin
®
, (generic)
600 mg q8h IV or
300-450 mg qid PO
Dicloxacillin (generic) 500 mg qid PO
Cephalexin
Keflex
®
, (generic)
500 mg qid PO
Doxycycline Vibramycin
®
, (generic)
Minocycline Minocin
®
, (generic)
100 mg bid PO
SMX-TMP Bactrim
®
, Septra
®
,
(generic)
One or two double-strength
tablets bid PO
