14
Treatment
Table 9. Common Medication Dosage for Rate Control of AF
Intravenous Administration
Usual Oral
Maintenance Dose
Beta blockers
Metoprolol tartrate 2.5-5.0 mg IV bolus over 2 min;
up to 3 doses
25-100 mg BID
Metoprolol XL
(succinate)
N/A 50-400 mg QD
Atenolol N/A 25-100 mg QD
Esmolol 500 mcg/kg IV bolus over
1 min, then 50-300 mcg/kg/min IV
N/A
Propranolol 1 mg IV over 1 min, up to
3 doses at 2-min intervals
10-40 mg TID or
QID
Nadolol N/A 10-240 mg QD
Carvedilol N/A 3.125-25 mg BID
Bisoprolol N/A 2.5-10 mg QD
Nondihydropyridine calcium channel antagonists
Verapamil 0.075-0.15 mg/kg IV bolus over
2 min, may give an additional
10.0 mg aer 30 min if no response,
then 0.005 mg/kg/min infusion
180-480 mg QD (ER)
Diltiazem 0.25 mg/kg IV bolus over 2 min,
then 5-15 mg/h
120-360 mg QD (ER)
Digitalis glycosides
Digoxin 0.25 mg IV with repeat dosing to a
maximum of 1.5 mg over 24 h
0.125-0.25 mg QD
Others
Amiodarone
a
300 mg IV over 1 h, then 10-50 mg/h
over 24 h
100-200 mg QD
a
Multiple dosing schemes exist for the use of amiodarone.
