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Factor Xa Inhibitor
Rivaroxaban Apixaban Edoxaban
Avoid use Avoid use Avoid use with
rifampin. No study
evaluated the effect of
other p-glycoprotein/
CYP 3A4 inducers on
edoxaban drug levels
No dose adjustment needed No dose adjustment needed No dose adjustment
needed
Avoid use Use with caution Use with caution
Avoid use Avoid use Avoid use
