26
Introduction
2.3. Mechanisms and Pathophysiology
Hypertension, valve
disease
Renin-angiotensin-
aldosterone system
(RAAS) activation
Fibrotic and
adipocyte signaling
Atrial hypertrophy,
cardiomyopathy
Coronary artery
disease
Hypoxia, ischemia
Systemic
inflammation
Slowed,
heterogeneous
atrial conduction
AF
Figure 7. Mechanisms and Pathways Leading to AF
e pathways that contribute to the development of AF create a substrate for re-entry and
provide triggers that can initiate arrhythmic activity.
