94
Management
Table 23. Specific Drug Therapy for Maintenance of Sinus
Rhythm in Patients With Atrial Fibrillation
Drug Loading Dose Maintenance Dose
Primary
Route(s) of
Elimination
Amiodarone Total loading
dose 6–10 g,
given 400–800
mg daily in 2–4
divided doses for
1–4 wk
200 mg once daily Liver
metabolism
Biliary
excretion
Dofetilide N/A CrCl > 60 mL/min: 500 µg
twice daily
CrCl 40–60 mL/min: 250 µg
twice daily
CrCl 20–40 mL/min: 125 µg
twice daily
CrCl < 20 mL/min:
Contraindicated
Kidney
