11
Table 3. Cockcroft-Gault Equation for Creatinine Clearance
Male: (140 – age in years) × (weight in kg ) ÷ (72 × serum creatinine)
Female: (140 – age in years) × (weight in kg ) × (0.85) ÷ (72 × serum creatinine)
Table 4. Child-Pugh Score
Component
Points Scored
1 2 3
Encephalopathy
a
None Grade 1–2 Grade 3–4
Ascites None Mild or controlled
by diuretics
Moderate or
refractory despite
diuretics
Albumin >3.5 g/dL 2.8–3.5 g/dL <2.8 g/dL
Total bilirubin
OR
<2 mg/dL
(<34 μmol/L)
2–3 mg/dL
(34–50 μmol/L)
>3 mg/dL
(>50 μmol/L)
Modified total
bilirubin
b
<4 mg/dL 4–7 mg/dL >7 mg/dL
Prothrombin
time (seconds
prolonged) or
<4 4–6 >6
International
normalized ratio
(INR)
<1.7 1.7–2.3 >2.3
a
Encephalopathy Grades
Grade 1: Mild confusion, anxiety, restlessness, fine tremor, slowed coordination
Grade 2: Drowsiness, disorientation, asterixis
Grade 3: Somnolent but rousable, marked confusion, incomprehensible speech, incontinence,
hyperventilation
Grade 4: Coma, decerebrate posturing, flaccidity
b
Modified total bilirubin used for patients who have Gilbert's syndrome or who are taking
indinavir or atazanavir
Child-Pugh Classification Total Child-Pugh Score
Class A 5–6 points
Class B 7–9 points
Class C >9 points
