11
Table 3. Injectable Depot Formulations
Medication
(Brand)
Recommended
Dose Range
(mg/day)
a
Half-life (hours) Drug Interactions
a
Atypical antipsychotic agents
Aripiprazole
(Abilify
Maintena
™
)
400 mg IM
monthly (may
reduce to 300)
400 mg-46.5 days
300 mg-29.9 days
CYP 3A4 and CYP 2D6
interactions but no specific
dose change recommendations
Olanzapine
(Relprevv
®
)
150 mg/2 wks,
300 mg/4 wks,
210 mg/2 wks,
405 mg/4 wks, or
300 mg/2 wks
(See PI for details)
~30 days Diazepam, alcohol, CYP 1A2
and CYP 2D6 interactions
but no specific dose change
recommendations
Paliperidone
(Invega
®
Sustenna
®
)
117 mg monthly 25-49 days CYP 3A4 interactions but
no specific dose change
recommendations
Risperidone
(Consta
®
)
25 mg/2 wks 3-6 days Avoid alcohol, levodopa,
dopamine, cimetidine,
ranitidine, clozapine,
fluoxetine, paroxetine and
carbamazepine interactions
a
Dose range recommendations are adapted from the 2009 Schizophrenia Patient Outcome
Research Team recommendations. See full prescribing information for details.
