10
Treatment
Table 2c. Commonly Used Medications
Medication
(Brand)
Recommended
Dose
a
Uses
Bupropion
(Wellbutrin)
150-450 mg/day Major depressive disorder,
seasonal affective disorder,
weight loss, smoking cessation. Issues
include abuse potential, 2D6 inhibition.
Benzodiazepines Various Agitation, insomnia, akathisia, anxiety
Benztropine
(Cogentin
®
, generic)
0.5-6 mg/day Parkinsonism, EPS
Beta Blockers Various Akathisia, impulsivity, aggression
Carbamazepine
(Tegretol
®
, generic)
400-1200 mg/day Seizures, mania, violence, treatment resistant
psychosis. Enzyme induction, 3A4, may
significantly lower some antipsychotic levels
Diphenhydramine
(Benadryl
®
)
25-300 mg/day Insomnia, EPS, EPS prophylaxis
Divalproex
(Depakote, generic)
Various Seizures, mania, migraine prophylaxis,
violence, treatment resistant psychosis
Lamotrigine
(Lamictal
®
, generic)
Various Seizures, bipolar depression, treatment
resistant psychosis
Lithium (Eskalith
®
,
generic)
900-1800 mg/day Mania
Metformin
(Fortamet
®
,
Glumetza, generic)
1000-2000 mg/day Diabetes mellitus, prophylaxis of weight
pain
Oxcarbazepine
(Trileptal
®
, generic)
1200-2400 mg/day Seizures, bipolar disorder
SNRIs Various Major depressive disorder, anxiety, chronic
neuropathic pain
SSRIs Various Major depressive disorder, anxiety, obsessive
compulsive disorder
Topiramate
(Topamax)
200-400 mg/day Partial onset or primary generalized tonic-
clonic seizures
Migraine prophylaxis, weight loss
Not for treatment of mania
Trazodone
(Oleptro®, Desyrel,
generic)
25-600 mg/day Insomnia, depression at higher doses
Trihexyphenidyl
(Artane
®
, generic)
1-15 mg/day Parkinsonism, EPS
Zolpidem (Ambien
®
)
5-10 mg/day Insomnia
a
Dose range recommendations are adapted from the 2009 Schizophrenia Patient Outcome
Research Team recommendations. See full prescribing information for details.
