Treatment
14
Table 2. Maintenance Therapy in Growing Patients with CAH
Drugs Total Daily Dose Daily Distribution
GCs: HC tablets 10–15 mg/m
2
• d 3 times • d
MCs: fludrocortisone
tablets
0.05–0.2 mg/d 1–2 times/d • d
Sodium chloride
supplements
1–2 g/d (17–34 mEq/d)
in infancy
Divided into several
feedings
ese doses and schedules are meant as examples and should not be construed as a restrictive menu
of choices for the individual patient.
Table 3. Maintenance Therapy Suggested in Fully Grown
Patients
Type of Long-Acting
Corticosteroid Suggested Dose (mg/d) Daily Doses
HC 15–25 2–3
Prednisone 5–7.5 2
Prednisolone
a
4–6 2
Methylprednisolone 4–6 2
Dex
a
0.25–0.5 1
Fludrocortisone 0.05–0.2 1–2
a
Suspension or elixir may permit improved dose titration for these drugs.
Table 4. Suggested Stress Doses of GC for Adrenal Crisis
Patient's Age Initial Parenteral HC Dose
Infants and preschool children 25 mg
School-age children 50 mg
Adults 100 mg
Successive IV HC may be administered as one-quarter of the initial parenteral HC dose (above)
given every 6 h.
