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Condenital Adrenal Hyperplasia

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Diagnosis 4 Figure 1. Fetal Adrenal Steroidogenesis Cholesterol Pregnenolone P450scc + StAR 17OH-Preg P450c17 DHEA P450c17+b 5 3βHSD2 Progesterone P450c21 3βHSD2 17OH-Progesterone (17OHP) P450c21 3βHSD2 Androstenedione P450c11β Androstenediol 17βHSD5 3βHSD2 Testosterone 5αR2 DHT Cholesterol Pregnenolone 17OH-Preg DHEA Androstenediol P450scc + StAR P450c17 P450c17+b 5 17βHSD5 170HP 3βHSD2 5αR1 5α-Pregnan- 17α-ol-3, 20-dione Reductive 3αHSD P450c17 17βHSD5 Androstenedione 3βHSD2 P450c17+b 5 Testosterone 5αR2 DHT 17βHSD5 3βHSD2 Oxidative 3αHSD (a) (b)

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