Timepoint/Frequency of Testing
Every 3-6
Months
Every 6
Months
Every 12
Months
Treatment
Failure
Clinically
Indicated
If abnormal at last
measurement
If normal at last
measurement
If abnormal at last
measurement
If normal at last
measurement
If on TDF
i
f
If HBsAg is positive at baseline or before initiation of ART, TDF plus either FTC or 3TC should
be used as part of the ARV regimen to treat both HBV and HIV infections. If HBsAg, and
HBsAb, and anti-HBc are negative at baseline, hepatitis B vaccine series should be administered.
Refer to HIV Primary Care guidelines for more detailed recommendations. (http://aidsinfo.nih.
gov/contentfiles/lvguidelines/adultandadolescentgl.pdf )
g
Serum Na, K, HCO
3
, Cl, BUN, creatinine, glucose (preferably fasting ). Some experts suggest
monitoring the phosphorus levels of patients on TDF. Determination of renal function should
include estimation of CrCl using the Cockcro-Gault equation or estimation of glomerular
filtration rate using the MDRD equation.
h
For patients with renal disease, consult the Guidelines for the Management of Chronic Kidney
Disease in HIV-Infected Patients: Recommendations of the HIV Medicine Association of the
Infectious Diseases Society of America.(http://cid.oxfordjournals.org/content/40/11/1559.full.
pdf+html)
i
More frequent monitoring may be indicated for patients with evidence of kidney disease (eg,
proteinuria, decreased glomerular dysfunction) or increased risk of renal insufficiency (eg, patients
with diabetes, hypertension).
11
