Key Points
2
Household Members (Table 1)
6. Immunocompetent household members of immunocompromised
patients can safely receive inactivated vaccines based on the
Centers for Disease Control and Prevention (CDC) Advisory
Committee on Immunization Practices (ACIP)'s annually updated
recommended vaccination schedules for children and adults
(hereafter referred to as the CDC annual schedule) (SR-H) or for
travel (SR-M).
7. Household members of immunocompromised patients 6 months
and older should receive influenza vaccine annually (SR-H). They
should receive either:
a. Inactivated influenza vaccine (IIV) (SR-H) or
b. Live attenuated influenza vaccine (LAIV) provided they are healthy, not
pregnant, and age 2-49 years (SR-L). Exceptions include household members
of an immunocompromised patient who is a hematopoietic stem cell
transplant (HSCT) recipient within 2 months after transplant or with graft-
vs-host disease (GVHD), or a patient with severe combined immunodeficiency
(SCID).* In these exceptions, LAIV should not be administered (WR-VL)
or, if administered, contact between the immunocompromised patient and
household member should be avoided for 7 days (WR-VL).
8. Healthy immunocompetent household members of
immunocompromised patients should receive the following live
vaccines based on the CDC annual schedule: combined measles,
mumps, and rubella vaccines (MMR) (SR-M), rotavirus vaccine in
infants ages 2-7 months (SR-L), varicella vaccine (VAR) (SR-M), and
zoster vaccine (ZOS) (SR-M). They can safely receive vaccines for
travel: yellow fever vaccine (SR-M), and oral typhoid vaccine (SR-L).
9. Oral poliovirus vaccine (OPV) should not be administered to
household members of immunocompromised patients (SR-M).
10. Highly immunocompromised patients should avoid handling diapers
of infants vaccinated with rotavirus vaccine for 4 weeks after
vaccination (SR-VL).
11. Immunocompromised patients should avoid contact with persons
who develop skin lesions after receiving VAR or ZOS until the
lesions have cleared (SR-L).
