Treatment
Table 3. Recommended Doses and Redosing Intervals for
Commonly Used Antimicrobials for Surgical Prophylaxis
Recommendations
Adult Half-Life
in Normal Renal
Function (hrs)d
Adult Dose
Ampicillin–
sulbactam
(Unasyn®)
3g
50 mg/kg
(ampicillin 2 g/ of the ampicillin
sulbactam 1 g) component
2 hrs
0.8-1.3
Ampicillin
(generic)
2g
50 mg/kg
2 hrs
1-1.9
Aztreonam
(Azactam®)
2g
30 mg/kg
4 hrs
1.3-2.4
Cefazoline
2 g;
(Kefzol ®, generic) 3 g for
≥120 kg
30 mg/kg
4 hrs
1.2-2.2
Cefuroxime
(Zinacef ®,
generic)
1.5 g
50 mg/kg
4 hrs
1-2
Cefotaxime
(Claforan®,
generic)
1 ge
50 mg/kg
3 hrs
0.9-1.7
Cefoxitin
(Mefoxin®,
generic)
2g
40 mg/kg
2 hrs
0.7-1.1
Cefotetan
(Cefotan®,
generic)
2g
40 mg/kg
6 hrs
2.8-4.6
Ceftriaxone
(Rocephin®,
generic)
2 gi
50-75 mg/kg
NA
5.4-10.9
Ciprofloxacinf
(Cipro®, generic)
400 mg
10 mg/kg
NA
3-7
Clindamycin
900 mg
(Cleocin®, generic)
10 mg/kg
6 hrs
2-4
Ertapenem
(Invanz®)
1g
15 mg/kg
NA
3-5
Gentamicing
(generic)
6
Pediatric Dose
Redosing
Intervalc,d
Antimicrobial
5 mg/kg
based on
dosing weight
(single dose)
2.5 mg/kg
based on dosing
weight
NA
2-3
a
b
