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Strength of Recommendation and Quality of Evidence Category/Grade Strength of Recommendation A B C Quality of Evidence I II III Definition Good evidence to support a recommendation for use Moderate evidence to support a recommendation for use Poor evidence to support a recommendation Evidence from ≥1 properly randomized, controlled trial Evidence from ≥1 well-designed clinical trial without randomization, from cohort or case-controlled analytic studies (preferably from >1 center), from multiple time-series, or from dramatic results from uncontrolled experiments Evidence from opinions of respected authorities based on clinical experience, descriptive studies, or reports of expert committees Source: Canadian Task Force on the Periodic Health Examination. Can Med Assoc J. 1979;121:1193-1254. Sources Centers for Disease Control and Prevention. Prevention and control of seasonal influenza with vaccines: recommendations of the Advisory Committee of Immunization Practices – United States, 2013-2014. MMWR Recomm Rep. 2013;62:1-43. Harper SA, Bradley JS, Englund JA, et al. Seasonal influenza in adults and children – diagnosis, treatment, chemoprophylaxis, and institutional outbreak management: clinical practice guidelines of the Infectious Diseases Society of America (IDSA). Clin Infect Dis. 2009;48:1003-1032. Disclaimer This Guideline attempts to define principles of practice that should produce high-quality patient care. It is applicable to specialists, primary care, and providers at all levels. This Guideline should not be considered exclusive of other methods of care reasonably directed at obtaining the same results. The ultimate judgment concerning the propriety of any course of conduct must be made by the clinician after consideration of each individual patient situation. Neither IGC, the medical associations, nor the authors endorse any product or service associated with the distributor of this clinical reference tool. IDSAINF13103 106 Commerce Street, Suite 105 Lake Mary, FL 32746  TEL: 407.878.7606  •  FAX: 407.878.7611  For additional copies: Copyright © 2013 All rights reserved

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