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Abbreviations ACCF, American College of Cardiology Foundation; ACE, angiotensin-converting enzyme; ACLS, advanced cardiac life support; ACS, acute coronary syndrome; ACT, activated clotting time, anticoagulation therapy; AHA, American Heart Association; ARB, angiotensin receptor blocker; ASA, aspirin; BMS, bare-metal stent; BNP, B-type natriuretic peptide; CABG, coronary artery bypass graft; CAD, coronary artery disease; CCS, Canadian Cardiovascular Society; CHD, coronary heart disease; CKD, chronic kidney disease; CK-MB, creatine kinase-MB; COPD, chronic obstructive pulmonary disease; COX, cyclooxygenase; D/C, discontinue; DES, drug-eluting stent; ECG, electrocardiogram; ED, emergency department; EMS, emergency medical services; GDMT, guideline-directed medical therapy; GI, gastrointestinal; GP, glycoprotein; GRACE, Global Registry of Acute Coronary Events; h, hour; HF, heart failure; IABP, intra-aortic balloon pump; ICH, intracranial hemorrhage; IV, intravenous; LAD, left anterior descending; LD, loading dose; LDL-C, low-density lipoprotein cholesterol; LOE, level of evidence; LV, left ventricular; LVEF, left ventricular ejection fraction; MACE, major adverse cardiac event(s); MD, maintenance dose; MI, myocardial infarction; MR, mitral regurgitation; NCEP, National Cholesterol Education Program; non-HDL-C, non–high-density lipoprotein cholesterol; NSAIDs, nonsteroidal antiinflammatory drugs; NTG, nitroglycerin; OASIS, Organization to Assess Strategies for Ischemic Syndromes; PCI, percutaneous coronary intervention; PLATO, Platelet Inhibition and Patient Outcomes study; PPI, proton pump inhibitor; SC, subcutaneous; SIHD, stable ischemic heart disease; STEMI, ST-elevation myocardial infarction; STS, Society of Thoracic Surgeons; SYNTAX, Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery; TIA, transient ischemic attack; TIMI, Thrombolysis in Myocardial Infarction; TnI, troponin I; TnT, troponin T; U, units; UA/NSTEMI, unstable angina/non–ST-elevation myocardial infarction; UFH, unfractionated heparin. Source Anderson JL, Adams CD, Antman EM, Bridges CR, Califf RM, Casey DE Jr, Chavey WE 2nd, Fesmire FM, Hochman JS, Levin TN, Lincoff AM, Peterson ED, Theroux P, Wenger NK, Wright RS. 2012 ACCF/AHA focused update incorporated into the ACCF/AHA 2007 guidelines for the management of patients with unstable angina/non–ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/ American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2013;61:e179-e347. Also printed in: Circulation. 2013;127:e663-e828. Disclaimer This Guideline attempts to define principles of practice that should produce high-quality patient care. It is applicable to specialists, primary care, and providers at all levels. This Guideline should not be considered exclusive of other methods of care reasonably directed at obtaining the same results. The ultimate judgment concerning the propriety of any course of conduct must be made by the clinician after consideration of each individual patient situation. Neither IGC, the medical associations, nor the authors endorse any product or service associated with the distributor of this clinical reference tool. ACCUAS04133a 106 Commerce Street Suite 105 Lake Mary, FL 32746 TEL: 407-878-7606 • FAX: 407-878-7611 For additional copies: info@GuidelineCentral.com Copyright © 2013 All rights reserved