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Mechanical Circulatory Support

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Table 5. INTERMACS Clinical Profiles Level Time Frame for Intervention Description Hemodynamic Status 1 Critical cardiogenic shock – "crash and burn" Persistent hypotension Within hours despite rapidly escalating inotropic support and eventually intraaortic balloon pump (IABP), and critical organ hypoperfusion 2 Progressive decline on inotropic support – "sliding on inotropes" Intravenous inotropic support with acceptable values of blood pressure and continuing deterioration in nutrition, renal function, or fluid retention Within days 3 Stable but inotrope dependent – "dependent stability" Stability reached with mild to moderate doses of inotropes but demonstrating failure to wean from them because of hypotension, worsening symptoms, or progressive renal dysfunction Elective over weeks   to months 4 Resting symptoms – "frequent flyer" Possible weaning of inotropes but experiencing recurrent relapses, usually fluid retention Elective over weeks   to months 5 Exertion intolerant, housebound Severe limited tolerance for activity, comfortable at rest with some volume overload and often with some renal dysfunction Variable urgency, dependent on nutrition and organ function 6 Exertion limited – "walking wounded" Less severely limited tolerance for activity and lack of volume overload, fatigue easily Variable urgency, dependent on nutrition and organ function 7 Advanced NYHA III – "symptoms, placeholder" Patient without current or recent unstable fluid balance, NYHA class II or III Not currently indicated

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