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Figure 1. HFr EF Stage C: Evidence-Based GDMT
HFr EF Stage C
NYHA Class I–IV
Treatment:
Class I,
LOE A
ACEI or ARB
AND beta
blocker
For persistently
symptomatic
African Americans,
NYHA class III–IV
For NYHA class II–IV
patients,
provided estimated
CrCl >30 mL/min
and K+ <5.0 mEq/dL
Add
Add
Add
Class I,
LOE C
Loop diuretics
Class I,
LOE A
Hydral-nitrates
Class I,
LOE A
Aldosterone
antagonist
For all volume
overload, NYHA class
II–IV patients
17
