Grading System
Strength of
Recommendation
Quality of Evidence
1 = strong
⊕⊕⊕⊕ = high
⊕⊕⊕ =
2 = weak
⊕⊕ = low
moderate
⊕ =
very low
Abbreviations
17-OHP, 17-hydroxyprogesterone; 3β-HSD, 3β-hydroxysteroid dehydrogenase; ACTH,
adrenocorticotropic hormone; BMD, bone mineral density; CAH, congenital adrenal
hyperplasia; D/C, discontinue; ES, Endocrine Society; GC, glucocorticoid; GYN, gynecologic;
HC, hydrocortisone; IV, intravenous; MC, mineralocorticoid; NCCAH, nonclassic CAH; PE,
physical examination; US, ultrasound
Source
Speiser PW, Azziz R, Baskin LS, et al; Endocrine Society. Congenital adrenal hyperplasia due to
steroid 21-hydroxylase deficiency: an Endocrine Society clinical practice guideline.
J Clin Endocrinol Metab. 2010;95(9):4133-4160. PMID: 20823466
Disclaimer
This Guideline attempts to define principles of practice that should produce high-quality patient care.
It is applicable to specialists, primary care, and providers at all levels. This Guideline should not be
considered exclusive of other methods of care reasonably directed at obtaining the same results. The
ultimate judgment concerning the propriety of any course of conduct must be made by the clinician after
consideration of each individual patient situation.
Neither IGC, the medical associations, nor the authors endorse any product or service associated with
the distributor of this clinical reference tool.
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