48
Management
Table 13A. Key Examples of Precision Medicine in IEI
Associated IEI Therapeutic agent
Innate immune disorders of IFN-γ signaling
IL-12 IL-23RB1 IFN-γ
IL-12p40 deficiency
IL-12RB2 deficiency
AD partial IFN-gR1 or R2 deficiency
STAT1 LOF
IRF8 deficiency
IFN-γ deficiency IFN-γ
Leukocyte adhesion disorder
LAD-II Fucose
Activate PI3K delta syndrome
APDS1 Leniolisib
APDS2
a
Biomarkers are recommended but are not included in the strength of recommendation and are
only provided as a guide to therapeutic efficacy.
(cont'd)
