41
Table 11. Vaccination Considerations in IEI
Vaccination
approaches
Associated
IEI
Vaccines of
relevance
Strength of
recommendation
Certainty
of
evidence
Vaccination
and boosters
with conjugated
vaccines for
patients at
risk for severe
bacterial
infections
Complement
deficiencies
Early administration
of MenACWY (<5 y);
followed by boosters
with MenACWY +
MenB vaccination,
or pentavalent
meningococcal vaccine
Strong Low
Asplenia/
hyposplenia
TLR defects
Primary vaccination or
completion of primary
series with conjugated
pneumococcal
vaccines
Catch-up and
"booster"
vaccines for
patients at risk
for serious
and/or chronic
viral infections
Defects in
cytotoxic
T cells;
NK cell
deficiencies
HPV vaccines Conditional Very low
Recombinant zoster
vaccine for shingles
Strong Very low
Vaccination
of household
contacts of
patients with
IEI
Household
contacts of
any patient
with IEI
Scheduled routine
vaccinations
are encouraged,
including routine live
viral vaccines, except
oral polio vaccine and
ACAM2000 mpox
vaccine
Strong Low
(cont'd)
