30
Management
Table 9A. Antibiotic Prophylaxis for Selected IEI
a
IEI
Indication for
prophylaxis Drug regimen
Chronic
mucocutaneous
candidiasis
Disseminated
candidiasis or
Coccidioidomycosis
Fluconazole 5 mg/kg
(STAT1 GOF,
APECED,
CARD9, IL17,
and IL17R
defects)
MSMD Mycobacterial
infections
Azithromycin (5 mg/kg/d max of 250 mg
daily or 500 mg 3d/wk)
CID with severe
T-cell defects
Pneumocystis
pneumonia
TMP/SMX (5 mg/kg max dose 160 mg
TMP component twice daily)
Alternatives:
pentamidine, atovaquone, dapsone
Chronic viral
infection
Acyclovir 5 mg/kg valacyclovir, ganciclovir
Valganciclovir 16 mg/kg/d
GI infection Azithromycin (5 mg/kg/d max of 250 mg
daily or 500 mg 3 d/wk)
a
Not an exhaustive list, alternative recommendations exist.
(cont'd)
