21
Table 7A. Examples of IEI Associated With Chronic Viral
Infections and Specific Nonviral Infections That
May Warrant Evaluation or Monitoring
Infectious
susceptibility IEI Associated genes
Herpes virus
family
SCID IL2RG, RAG1, RAG2, ADA, JAK3,
IL7R, DCLRE1C, NHEJ1, LIG4,
RMRP
FHL PRF1, UNC13CD, STX11, STXBP2
NK deficiencies MCM4, GATA2, IRF8, RTEL1,
FCGR3A
CTLA-4 haploinsufficiency CTLA-4
LRBA deficiency LRBA
Activated phosphoinositide
3-kinase delta syndrome
(APDS)1, 2
PIK3CD, PIK3R1
DOCK8 deficiency DOCK8
DOCK2 deficiency DOCK2
EBV XLP1, 2 SH2D1A, BIRC4/XIAP
ITK deficiency ITK
CD27 deficiency CD27
CD70 deficiency CD70
XMEN MAGT1
Coronin 1A deficiency CORO1A
STK4 deficiency STK4
STAT1 deficiency STAT1
BENTA CARD11
CARMIL2 deficiency CARMIL2
PRKCD deficiency PRKCD
RASGRP1 deficiency RASGRP1
CTPS1 deficiency CTPS1
CD137 deficiency TNFRSF9
COPG1 deficiency COPG1
HELIOS, AIOLOS IKZF2, IKZF3
CHH RMRP
