23
Table 7A. Examples of IEI Associated With Chronic Viral
Infections and Specific Nonviral Infections That
May Warrant Evaluation or Monitoring
Infectious
susceptibility IEI Associated genes
Varicella zoster
virus (VZV)
WAS WAS
Ataxia telangiectasia ATM
RNA polymerase III def. POLR3A, 3C, 3F
TLR3 deficiency TLR3
WHIM syndrome CXCR4
STAT5B deficiency STAT5B
GINS1 deficiency GINS1
Moesin deficiency MSN
CTPS1 deficiency CTPS1
CHH RMRP
HPV WHIM syndrome CXCR4
Epidermodysplasia
verruciformis
EVER1, EVER2
C1B1 deficiency C1B1
STK4 deficiency STK4
Ataxia telangiectasia ATM
RHOH deficiency RHOH
CD28 deficiency CD28
LAD1 ITGB2
NEMO NFKB1A
WAS WAS
Comel-Netherton
syndrome
SPINK5
Cryptosporidium
spp.
NIK deficiency MAP3K14
Hyper IgM syndrome CD40LG, CD40
IL21, IL21R deficiency IL21, IL21R
DOCK8 deficiency DOCK8
Mycobacterium
spp.
MSMD IL12RB1, IL12B, IL12RB2, IL23R,
IFNGR1, IFNGR2, STAT1 LOF,
IFNG, IRF8, CYBB, ISG15, TYK2,
SPPL2A, IKBKG, JAK1, RORC
GATA2 deficiency GATA2
(cont'd)
