39
Examples
Aplasia cutis Omphalocele
Methimazole or carbimazole
b
Odds ratio 0.1 0.2 0.4 1 2 4 8 12 20
Musculoskeletal system
Eye
Integumentary system
Digestive system
Urinary system
Respiratory system
Circulatory system
MMI/CMZ use only Both PTU and MMI/CMZ
8.1%
(N=91/1,120)
8.0%
(N=147/1,841)
9.1%
(N=100/1,097)
10.1%
(N=16/159)
e relative and absolute risks, as well as examples of affected organ systems and severity of congenital
malformations, associated with maternal antithyroid drug use during pregnancy are summarized from
data reported in two large epidemiologic studies.
