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Thyroid Disease in Preconception, Pregnancy, and Postpartum

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Physiology, Laboratory Testing, and Iodine 14 Recommendations Table 3. Iodine Nutrition Strength * Level # Pregnant and lactating women should strive for a daily iodine intake of 250 mcg as provided by dietary iodine intake complemented by iodine supplements as required. Strong Moderate For women at risk of iodine deficiency given geographic region, dietary restrictions or malabsorption, we suggest starting 150 mcg per day iodine supplementation ideally at least 3 months before planned pregnancy and continued until lactation is complete. Conditional Moderate An annual dose of 400 mg iodized oil in women of childbearing age and pregnant women can be given in low-resource countries and/or regions with severe iodine deficiency, where neither salt iodization nor daily iodine supplements are feasible. Conditional Moderate We suggest applying similar iodine supplementation recommendations for pregnant women taking antithyroid drugs (ATDs) for Graves' hyperthyroidism and those taking levothyroxine for hypothyroidism. Conditional Low Excessive iodine exposure during pregnancy should be avoided with the exception of certain medical indications, such as the use of saturated solution of potassium iodide (SSKI) or iodinated contrast media. Strong Moderate Sustained excessive dietary iodine intake and dietary supplements use exceeding 500 mcg daily should be avoided during pregnancy due to concerns for fetal and maternal thyroid dysfunction. Strong Moderate * Strength of Recommendation; # Level of Evidence; Good Practice Statement.

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