OMA Guidelines Bundle

17 Key Interactions/Notes Avg. ΔWt vs. Placebo Carbonic anhydrase inhibitors (CAIs) (eg, topiramate, zonisamide) lactic acidosis risk ~3% Delays gastric emptying → may delay absorption of oral meds ~5% Effect of OCs; potentiates central nervous system (CNS) depressants and hypokalemia with non–K-sparing diuretics ~2–5% CYP2D6 inhibitor ~4–5% CYP2D6 substrate ~5% CYP3A4 metabolism ~3.1–5%

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