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Obesity Pharmacotherapy Supplements 2026

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Abbreviations ALA, alpha lipoic acid; α-MSH, α-melanocyte stimulating hormone; ACE, angiotensin-converting enzyme blockers; ADHD, attention-deficit hyperactivity disorder; ARBs, angiotensin II receptor blockers; BBS, Bardet-Biedl syndrome; BED, binge-eating disorder; BP, blood pressure; CAIs, carbonic anhydrase inhibitors; CCBs, calcium channel blockers; CNS, central nervous system; DPP-4, dipeptidyl peptidase-4; FDA, US Food and Drug Administration; GABA, gamma-aminobutyric; GI, gastrointestinal; GIP, glucose-dependent insulinotropic polypeptide; GLP-1, glucagon- like peptide-1; HA, headache; HCl, phentermine hydrochloride; HR, heart rate; IUD, intrauterine device; KATP, ATP-sensitive potassium channel; LEPR, leptin receptor; MAOI, monoamine oxidase inhibitor; MC4R, melanocortin-4 receptor; NDRI, norepinephrine-dopamine reuptake inhibitor; N/V, nausea/vomiting; OCs, oral contraceptives; OTC, over- the-counter; PCSK1, pproprotein convertase subtilisin/kexin type 1; PO, by mouth; POMC, proopiomelanocortin; RA, receptor agonist; SGLT2, sodium-glucose cotransporter 2; SSRIs, selective serotonin reuptake inhibitors; SU, sulfonylureas; T1DM, type 1 diabetes mellitus; T2DM, type 2 diabetes mellitus; TCA, tricyclic antidepressant; URTI, upper respiratory tract infection Source Tondt J, Orr M, Damian A, Magee J, Okubo N, Manalac R, Othman A, Karjoo S, Rajpal A, Hooper J, Busse M, Copeland P, Corrado R, Jain S, Bowlin S, George Jr T, Frederiksen K, Pennings N. Obesity Algorithm Slides, presented by the Obesity Medicine Association. www.obesityalgorithm.org. 2026. https://obesitymedicine.org/resources/ obesity-algorithm/. (Accessed = March 2026) Disclaimer is resource is for informational purposes only, intended as a quick-reference tool based on the cited source guideline(s), and should not be used as a substitute for the independent professional judgment of healthcare providers. Practice guidelines are unable to account for every individual variation among patients or take the place of clinician judgment, and the ultimate decision concerning the propriety of any course of conduct must be made by healthcare providers aer consideration of each individual patient situation. Guideline Central does not endorse any specific guideline(s) or guideline recommendations and has not independently verified the accuracy hereof. Any use of this resource or any other Guideline Central resources is strictly voluntary. 1258 Upsala Rd Sanford, FL 32771 TEL: 407.878.7606 Copyright © 2026 All rights reserved Obesity Medicine Association 7173 S. Havana St #600–130 Centennial, CO 80112 TEL: 303.770.2526 OMAOBEPS03263b

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