13
Common AEs Key Interactions/Notes Side Effects
Palpitations, heart rate
(HR)/blood pressure
(BP), restlessness,
dizziness, insomnia,
mood changes, HA,
dry mouth, diarrhea/
constipation
Avoid MAOIs (within
14 days); avoid other
sympathomimetics,
alcohol, adrenergic
neuron blockers, some
anesthetics
~5%
Common AEs Key Interactions/Notes
Avg. Wt Loss
vs. Placebo
Injection site
rxns, skin
hyperpigmentation,
nausea, HA,
diarrhea, abd/
back pain, fatigue,
upper respiratory
tract infection
(URTI), depression,
spontaneous penile
erection
No major known interactions Varies:
POMC/PCSK1
23% to 34%;
LEPR ~10–13%;
BBS ~7.9%
HA, hypoglycemia,
abd pain; weight
Potentiates hypoglycemic
agents
~4–14%
(by baseline
leptin)
Hypertrichosis,
edema,
hyperglycemia,
rash, fever,
arthralgia
CYP1A2/3A4 substrate;
oxidation/sulfate metabolism
No signif icant
weight change
(fat mass,
lean mass)
