11
Common AEs Key Interactions/Notes
Avg. Wt Loss
vs. Placebo
Oily stools/flatus
(esp. high-fat meals),
gallstones, kidney
stones, fat-soluble
vitamins
May reduce absorption
of cyclosporine, oral
contraceptives (OCs),
antiseizure meds, thyroid
hormone, warfarin; take
multivitamin ≥2 h apart
~2.9%
Nausea, constipation/
diarrhea, headache
(HA), vomiting,
dizziness, insomnia, dry
mouth
Avoid opioids, MAOIs;
interactions with
antiseizure meds;
potential to lower seizure
threshold; rare angle-
closure glaucoma;
suicidality risk <24 y with
bupropion
~5%
As phentermine
+paresthesia, dizziness,
dysgeusia; monitor
mood/sleep, cognition;
metabolic acidosis,
nephrolithiasis
Teratogenic, conf irm not
pregnant; avoid MAOIs
and alcohol; caution with
non-K sparing diuretics
(hypokalemia)
~9%
Nausea, vomiting,
bloating, diarrhea/
constipation, dyspepsia,
abd pain, fatigue,
dizziness, HA; lipase;
rare renal issues
Can worsen diabetic
retinopathy; stop if
pancreatitis, gallbladder
disease, suicidality;
hypoglycemia with insulin/
sulfonylureas (SU); slows
gastric emptying (affects
oral meds incl. OCs)
~4.5%
Similar to liraglutide
(primarily GI)
Same precautions as
liraglutide
~12.4%
Similar to
liraglutide; fewer GI
discontinuations vs
semaglutide
Same class precautions as
GLP-1 RAs
~18.4%
