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AHA/ASA Early Management of Acute Ischemic Stroke 2026

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54 In-Hospital Management of AIS: Treatment of Acute Complications 6.4. Cerebellar Infarction (Surgical Management) COR LOE Recommendations 1 C-LD 1. In patients with cerebellar infarction and obstructive hydrocephalus, ventriculostomy is recommended to improve neurological function and decrease mortality. Concomitant or subsequent decompressive craniectomy may or may not be necessary on the basis of factors such as the size of the infarction, neurological condition, degree of brainstem compression, and effectiveness of medical management. 1 B-R 2. In patients with cerebellar infarction causing neurological deterioration from brainstem compression or volumes ≥35 mL, decompressive suboccipital craniectomy with dural expansion should be performed to improve outcomes and decrease mortality. 6.3. Supratentorial Infarction (Surgical Management) COR LOE Recommendations 2a B-NR 1. In patients with large territorial cerebral infarctions at high risk for developing brain swelling and herniation, decreased level of consciousness attributed to brain swelling is a reasonable trigger for decompressive hemicraniectomy selection. 1 A 2. In patients ≤60 years of age with unilateral MCA infarctions who deteriorate neurologically within 48 hours from brain swelling despite medical therapy, decompressive craniectomy with dural expansion is beneficial to reduce mortality and improve functional outcome. 2b B-R 3. In patients >60 years of age with unilateral MCA infarctions who deteriorate neurologically within 48 hours from brain swelling despite medical therapy, decompressive craniectomy with dural expansion may be considered to reduce mortality. 2b B-NR 4. In patients with AIS who received IV tPA thrombolysis and develop malignant cerebral edema despite medical therapy, early decompressive craniectomy within 48 hours may still be considered without additional safety concerns.

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