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AHA/ASA Early Management of Acute Ischemic Stroke 2026

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36 General Supportive Early Management 4.7.2. Endovascular Thrombectomy for Adult Patients COR LOE Recommendations rombectomy 0 to 6 Hours Aer Onset of Symptoms, ASPECTS 0 to 2 2a B-R 4. (New and of High Impact) In selected patients † with AIS from anterior circulation proximal LVO of the ICA or M1 presenting within 6 hours from onset of symptoms, with age <80 years, NIHSS score ≥6, prestroke mRS 0 to 1, ASPECTS 0 to 2, and without significant mass effect on imaging, EVT is reasonable to improve functional clinical outcomes and reduce mortality. rombectomy 0 to 6 Hours Aer Onset of Symptoms With Mild Preexisting Disability 2a B-NR 5. (New and of High Impact) In patients with AIS from anterior circulation proximal LVO of the ICA or M1 presenting within 6 hours from onset of symptoms, with NIHSS score ≥6, and ASPECTS ≥6, who have a prestroke mRS score of 2, EVT is reasonable to improve functional clinical outcomes and reduce accumulated disability. rombectomy 0 to 6 Hours Aer Onset of Symptoms With Moderate Preexisting Disability 2b B-NR 6. In patients with AIS from anterior circulation proximal LVO of the ICA or M1 presenting within 6 hours from onset of symptoms, with NIHSS score ≥6, and ASPECTS of ≥6, who have a prestroke mRS score of 3 to 4, EVT might be reasonable to improve functional clinical outcomes and reduce accumulated disability. rombectomy 0 to 6 Hours for Dominant Proximal M2 Division MCA Occlusions 2a B-NR 7. In patients with AIS from occlusion of the dominant proximal M2 division of the MCA presenting within 6 hours from onset of symptoms with a prestroke mRS score of 0 to 1, NIHSS score of ≥6, and ASPECTS of ≥6, EVT is reasonable to improve functional outcomes, but the benefits are uncertain. (cont'd)

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