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3.6.2. Heart Transplantation and MCS
COR LOE
Recommendations
1 B-NR
1. In patients with ACHD and heart failure, evaluation by
specialists with medical and surgical experience in ACHD, as
well as by specialists with expertise in advanced heart failure,
is recommended to assess appropriateness for advanced heart
failure therapies, such as heart transplantation or MCS.
2a B-NR
2. In patients with ACHD who are considered for heart
transplantation, multiorgan transplantation (heart-lung,
heart-kidney, or heart-liver) is reasonable based on center-
specific assessment of the degree of respective lung, kidney, or
liver dysfunction.
2a B-NR
3. In patients with ACHD and advanced heart failure that is
refractory to optimal medical and device-based therapy, the
use of durable MCS devices is reasonable to improve quality
of life or as a bridge to transplantation.
3.7. Genetic Syndromes Screening
COR LOE
Recommendations
2a B-NR
1. For adults with conotruncal defects, screening for 22q11.2
deletion syndrome is reasonable to assess the risk of
transmission to offspring and to screen for associated
comorbidities.
2a C-EO
2. In adults with congenital heart disease and a family history of
congenital heart disease or clinical features associated with a
genetic syndrome, referral for genetic evaluation is reasonable
to guide management.
