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Adults with Differentiated THyroid Cancer - 2025 Update

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Key Points 4 Treatment Definitions Extent of Surgery Definitions (ATA Website Definitions) ➤ Total thyroidectomy: Surgical removal of the entire thyroid gland. ➤ Near-total thyroidectomy: Intended extent of resection for thyroid cancer is total thyroidectomy, but a small remnant may be left for a specific reason (usually confidence in nerve preservation). ➤ Lobectomy or hemithyroidectomy with or without isthmusectomy: Surgical removal of one lobe (half) of the thyroid with or without the isthmus. ➤ Subtotal thyroidectomy: Surgical removal of almost all of the thyroid gland, leaving 3–5 grams of thyroid tissue with the intent of maintaining adequate thyroid hormone production. This operation is not recommended if the diagnosis of thyroid cancer is known preoperatively. ➤ Completion thyroidectomy: Surgical removal of the remnant thyroid tissue following procedures of less than total or near-total thyroidectomy. Extent of Lymphadenectomy Definitions ➤ Central neck dissection: Central neck lymph nodes include Levels VI and VII (Figure 3). Central neck dissection is a comprehensive removal of pretracheal and prelaryngeal lymph nodes, along with at least one paratracheal nodal basin. It can be unilateral or bilateral; the laterality and extent of dissection should be documented at the time of operation in addition to surgical intent (therapeutic vs prophylactic). ➤ Therapeutic: Implies that metastatic nodal disease is apparent clinically preoperatively or intraoperatively by examination and/or imaging, cN1a. ➤ Prophylactic: Implies that no metastatic nodes are detected by examination or imaging preoperatively or intraoperatively, cN0. ➤ Lateral neck dissection: Full compartment dissection of the lateral cervical neck lymph nodes in Levels IIA, III, IV, and VB ipsilateral to the tumor and performed for clinical evidence of metastatic involvement. Dissection of Levels I, IIB and VA are not regularly performed but can be considered based on findings suggestive of metastatic disease in these compartments (Figure 3).

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