Tables and Figures
30
Table 4. Syndromes Associated With DTC
Syndrome
(gene) Histology
Lifetime
risk Other features Screening guidance
Cowden/
PTHS
syndrome
(PTEN)
FTC
a
,
PTC
3–10% Breast cancer,
endometrial
cancer, goiter,
macrocephaly
NCCN – Genetic/
Familial High-Risk
Assessment: Breast,
Ovarian, and Pancreatic
Familial
adenomatous
polyposis
(APC)
CMTC,
PTC
Up to
12%
Colon polyposis,
CHRPE,
desmoids
NCCN – Genetic/
Familial High-Risk
Assessment: Colorectal
DICER1
tumor
predisposition
(DICER1)
PTC,
FTC
a
,
PDTC
OR,
9.2 [CI,
2.1–34.7]
Pleuropulmonary
blastoma, cystic
nephroma, ovarian
sex cord stromal
tumors
Schultz et al.
Clin Cancer Res
2018;24(10):2251-
2261, doi:
10.1158/1078-0432.
Ccr-17-3089
Carney
complex
(PRKAR1A)
FTC
a
,
PTC
Unknown Pigmented
abnormalities of
the skin, myxomas,
schwannomas, and
endocrine tumors
Correa et al.
Eur J Endocrinol
2015;173(4):M85–97,
doi: 10.1530/eje-15-
0209
Werner
syndrome
(WRN)
FTC
a
,
PTC
Unknown Premature aging,
cataracts, DM,
other cancers
Takemoto et al.
Geriatr Gerontol Int
2021;21(2):131–132,
doi: 10.1111/ggi.14074
a
OTC was previously included as a subtype of FTC and is likely also associated with these hereditary
predispositions.
Table 5. Extent of Initial Thyroid Surgery for DTC
Clinical stage
Extent of thyroidectomy
a
cT1N0M0 (Unilateral) Lobectomy
cT1(m)N0M0 (Bilateral) Total thyroidectomy
cT2N0M0 (Unilateral) Lobectomy or Total thyroidectomy
cT2(m)N0M0 (Bilateral) Total thyroidectomy
cT3–4 or cN1 or cM1 Total thyroidectomy
Clinical stage based upon AJCC 8th edition.
a
If surgery chosen for initial therapy.
