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High Blood Pressure - Merck Supported

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75 Table 25. Patient Selection for Renal Denervation Resistant hypertension OR uncontrolled hypertension* • Patients with stage 2 hypertension (with both office SBP ≥140 mm Hg and office DBP ≥90 mm Hg ) in whom BP is not at goal despite taking ≥4 antihypertensive medications at optimal dosages (ACEi/ARB + CCB + thiazide-type diuretics, and MRA) • Patients with stage 2 hypertension (with both office SBP ≥140 mm Hg and office DBP ≥90 mm Hg ) who are unable to take antihypertensive medications at the optimal dosages or additional medications Contraindications • Neurogenic orthostatic hypotension • Pregnancy • Fibromuscular dysplasia • Stented renal artery • Renal artery aneurysm • Significant renal artery stenosis • Known kidney or secreting adrenal tumors * Aer evaluation by a multidisciplinary team to screen for secondary hypertension and contraindications and following a shared decision-making process.

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