43
Daily
Frequency Comments
1 Nebivolol induces nitric oxide-induced vasodilation.
Avoid abrupt cessation.
1 Avoid use in patients with reactive airways disease.
Avoid abrupt cessation.
2
1
2 Generally avoid, especially in patients with CHD or HF.
Avoid abrupt cessation.
1
2
2 Use of carvedilol is preferred in patients with HFrEF.
Avoid abrupt cessation.
1
2
1 Do not use in combination with ACEi or ARB.
Aliskiren is very long acting.
ere is an increased risk of hyperkalemia in CKD or in those on
K+ supplements or K+-sparing drugs.
Aliskiren may cause acute renal failure in patients with severe
bilateral renal artery stenosis.
Avoid use in pregnancy.
1 ese are associated with orthostatic hypotension, especially in older
adults with a greater BP drop with first dose effect.
ese may be considered a second-line agent in patients with
symptomatic benign prostatic hypertrophy.
2 or 3
1 or 2
2 ese are generally reserved as last-line choices because of significant
CNS adverse effects, especially in older adults.
Avoid abrupt discontinuation of clonidine, which may induce
hypertensive crisis.
Clonidine must be tapered to avoid rebound hypertension.
1 weekly
2
1
