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Comments
Contraindicated in reactive airway or obstructive pulmonary disease. Especially useful
in hyperadrenergic syndromes. May worsen HF and should not be given in patients with
second- or third-degree heart block or bradycardia.
Used in hypertensive emergencies induced by catecholamine excess
(pheochromocytoma, interactions between monamine oxidase inhibitors and other
drugs or food, cocaine toxicity, amphetamine overdose, or clonidine withdrawal).
Contraindicated in patients at risk of increased intraocular pressure (glaucoma) or
intracranial pressure and those with sulfite allerg y.
Contraindicated in pregnancy and should not be used in acute MI or bilateral renal
artery stenosis.
Mainly useful in hypertensive emergencies associated with high plasma renin activity.
Poorly defined dose adjustments for kidney failure and may worsen kidney injury in
those with CKD. Relatively slow onset of action (15 min) and unpredictability of BP
response.
