39
Daily
Frequency Comments
1 Chlorthalidone has a longer half-life and is more potent than
hydrochlorothiazide on a mg-to-mg basis.
Monitor for hyponatremia and hypokalemia, increased glucose, uric
acid, and calcium levels.
Monitor patients with history of acute gout unless patient is on uric
acid-lowering therapy.
1
1
1 or 2 Do not use in combination with ARB or direct renin inhibitor.
ere is an increased risk of hyperkalemia, especially in patients with
CKD or in those on K+ supplements or K+-sparing drugs.
ere is a risk of acute renal failure in patients with severe bilateral
renal artery stenosis.
Do not use if patient has history of angioedema with ACEi.
Avoid use in pregnancy.
2 or 3
1 or 2
1
1
1 or 2
1
1 or 2
1 or 2
1
1 Do not use in combination with ACEi or direct renin inhibitor.
ere is an increased risk of hyperkalemia in CKD or in those on
K+ supplements or K+-sparing drugs.
ere is a risk of acute renal failure in patients with severe bilateral
renal artery stenosis.
Do not use if patient has history of angioedema with ARBs. Patients
with a history of angioedema with an ACE inhibitor can receive an
ARB beginning 6 weeks aer ACE inhibitor is discontinued.
Avoid use in pregnancy.
1
1 or 2
1
1 or 2
1
1
1
1 Associated with dose-related lower extremity edema, which is more
common in women than men.
1
2
2
1
1
