ASAM Pocket Guidelines and Patient Guide

ASAM Opioid Use Disorder Patient Guide 2025

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© 2025 American Society of Addiction Medicine. All rights reserved. ASAM.org 22 OVERDOSE REVERSAL MEDICATION Naloxone is used to treat an opioid overdose (it works only for overdoses from opioids). It is available as a nasal spray and in an injectable form. A new medication, nalmefene, was recently approved by the FDA to treat opioid overdose. However, naloxone is less expensive, more readily available, and currently the preferred medication for reversing an opioid overdose. Having naloxone available can help to save a person who has taken so much opioid that they stop or have trouble breathing. If an overdose is suspected, call 911 immediately and give naloxone as soon as possible. More than one dose of naloxone may be needed to reverse an overdose of high potency opioids, such as fentanyl. Naloxone may need to be given multiple times since its effects may wear off before the opioid does. To ensure patient safety, patients, their family members, significant others, and friends should keep naloxone on hand and should be trained in its use in case of overdose. The clinician should provide naloxone, or a prescription for naloxone, for both the patient and family members. In most states, naloxone is also available without a prescription through the pharmacy. After patients overdose it is important that they either begin treatment for opioid addiction or work with their clinician to adjust their treatment plan.

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