21
Onset of action (min)
b
Elimination half-life (h)
c
Metabolism
d
15–30 6–12 CYP3A4
15–30 5–10
36–200 (AM)
CYP3A4
15–30 18–50 CYP3A4
15 CYP2C19
CYP3A4
≤15 20–100
36–200 (AM)
CYP1A2
CYP2C9
CYP2C19
CYP3A4
30–60 10–24 CYP3A4
≤15 40–250 (AM) CYP2C19
CYP3A4
15–30 10–20 Glucuronide conjugation
30–60 4–15 Glucuronide conjugation
15 39
73 (AM)
CYP2C9
CYP2C19
CYP3A4
30–60 10–20 Glucuronide conjugation
15–30 1.5–5 CYP3A4
