15
Table 5. Relative Infant Dose (RID) of BZD Medications
Medication
a
RID
b
Alprazolam 2–9%
Chlordiazepoxide Unknown
Clonazepam 2.5–4.6%
Clorazepate Unknown, shares metabolite with diazepam
Diazepam Up to 11%
Estazolam Unknown
Flurazepam Unknown
Lorazepam
c
0.7–4.4%
Oxazepam 10–33%
Quazepam 0.2–2.5%
Temazepam Dose dependent 0–10%
Triazolam Unknown
a
All BZDs are expected to cross placenta.
b
For optimal safety, the target RID is <10%.
c
Lorazepam is generally preferred in pregnancy and lactation due to its lack of active
metabolites and low RID.
