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• Modafinil: Modafinil is FDA-approved for the treatment of
narcolepsy, obstructive sleep apnea, and shift work-related
sleep disorder. It can help patients reduce cocaine use. This
medication is less effective if the patient has an alcohol use
disorder.
• Extended-release mixed amphetamine salts plus
topiramate: Extended-release mixed amphetamine salts (such
as Adderall and Mydayis) are FDA-approved for the treatment
of Attention Deficit Hyperactivity Disorder (ADHD). This
medication, combined with topiramate, may help reduce
cocaine craving.
• Extended-release Methylphenidate: Methylphenidate is
FDA-approved for the treatment of ADHD. This medication
may help a patient reduce their use of methamphetamine and
similar drugs.
STIMULANT MEDICATIONS
The medications in red are stimulant medications. These
medications have higher risks for patients with stimulant use
disorder than non-stimulant medications. They should only
be prescribed by a specialist such as an addiction medicine
or addiction psychiatry doctor. Prescribing stimulant
medication for patients with stimulant use disorder is
complex. For many patients with stimulant use disorder the
risks of these medications outweigh the benefits. If these
medications are prescribed, your doctor will closely monitor
your progress. They will check to see if you are taking the
medication as prescribed. They will also use drug testing
to see what other substances you may be taking. They will
review how the medication may be helping or harming you.
They will stop the medication if it is harming you more than
it is helping.
