24
Treatment
Table 2. Medications for Managing Intoxication
a
Agent/Class Mechanism Example dosing
Antipsychotics
Butyrophenones
(2nd gen)
Dopamine antagonism Haloperidol or droperidol 5 mg IM
Atypical Dopamine antagonism
+/– other
Olanzapine 5 mg PO
Quetiapine 50–100 mg PO at night
Other
Ketamine NMDA receptor
antagonism
1–5 mg/kg IM depending on degree
of agitation
a
e information in this table is intended to guide management of stimulant intoxication
in a variety of settings. e choice of medication, medication dosing (including initial
and redosing ), and route of administration should be guided by the patient's signs and
symptoms, degree of intoxication, the level of care, and the resources of the setting. is does
not represent a comprehensive list but rather provides illustrative examples of medications
discussed in the narrative.
(cont'd)
