9
Table 1. Medication Dosing in Clinical Trials
a
Drug Dose SUD
Modafinil 100–400 mg/day (or 200 mg
BID)
Cocaine
Modafinil 400 mg/day Cocaine, ATS
Topiramate + MAS-ER Topiramate max 100–150 mg
BID + MAS-ER max 60 mg/day
Cocaine
MAS-ER 60–80 mg/day Cocaine
Dextroamphetamine
(d-AMP-SR)
20–60 mg/day Cocaine
Methylphenidate ER 54–72 mg/day ATS
Methylphenidate SR 20–40 mg BID Cocaine
Methylphenidate SR 54 mg/day ATS
Methylphenidate short acting 20–60 mg/day
(Mean 37.6 mg/day
b
)
ATS
Methylphenidate 5–10 mg/day ATS
a
is appendix presents a summary of dosing strategies used in the clinical trials reviewed, but
is not intended as a dosing guide.
See full text guideline appendices for references. Available at: https://www.asam.org/
quality-care/clinical-guidelines/stimulant-use-disorders.
b
Patients self-titrated within this dose range.
ATS, amphetamine-type stimulant; BID, two times per day; d-AMP, dextroamphetamine;
d-AMP-SR, sustained-release dextroamphetamine; ER, extended release; LDX,
lisdexamfetamine; MAS-ER, extended-release mixed amphetamine salts; SR, sustained
release
