9
Laboratory mitigation Estimate of prevalence
Method comparison — different antibody species/label.
Immunosubtraction, e.g., polyethylene glycol (PEG)
a
precipitation.
Linearity/dilution studies.
Withdraw biotin and resample. Heterophile blocking
reagents.
Assay-dependent heterophile
~0.4%
Method comparison — different antibody species/label.
Equilibrium dialysis.
Unknown
Immunosubtraction, e.g.,
PEG precipitation.
Linearity/dilution studies.
Gel filtration chromatography.
~0.17%
Method comparison with two-step method/
equilibrium dialysis.
Immunosubtraction, e.g., PEG precipitation.
1.8%
c
Assay-dependent method comparison. Assay-specific allele frequency
0.13% (gnomAD v 2.1.1)
Assay-dependent method comparison. Equilibrium
dialysis.
Alb, TRR gene sequencing
Most common allele
familial dysalbuminemic
hyperthyroxinemia p.Arg242His
0.007% DTH p.Ala129Thr
0.003% (gnomAD v 2.1.1)
d
Predose sample, analyze immediately.
Predose sample, exchange medication.
Not available
Assay specific
